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The American Psychiatric Association Practice Guideline for the Treatment of Patients with Schizophrenia, Third Edition

American Psychiatric Association

  • 2021
  • 310 Pages
  • ISBN 978-0-89042-474-2
  • Item #2474


Worldwide, schizophrenia is one of the top 20 causes of disability. The lifetime prevalence of schizophrenia is estimated to be approximately 0.7%, although findings vary depending on the study location, demographic characteristics of the sample, the approach adopted for case finding, the method employed for diagnostic confirmation, and the diagnostic criteria used. Economic burdens associated with schizophrenia are high, with an estimated cost of more than $150 billion annually in the United States on the basis of 2013 data. Additional research since the second edition of the guideline has expanded our knowledge of the effective and evidence-based interventions available to help reduce the mortality, morbidity, and significant psychosocial and health consequences of this important psychiatric condition.

The American Psychiatric Association Practice Guideline for the Treatment of Patients With Schizophrenia seeks to reduce these substantial psychosocial and public health consequences for the individuals affected by schizophrenia. The guideline focuses specifically on evidence-based pharmacological and nonpharmacological treatments for schizophrenia and includes statements related to assessment and treatment planning, which are an integral part of patient-centered care. The guideline provides direction on implementing these recommendations into clinical practice, with the goal of improving the quality of care and treatment outcomes for patients with schizophrenia.


    Chapter 1. Rationale
    Chapter 2. Guideline Statement Summary
    Chapter 3. Guideline Statements and Implementation
    Chapter 4. Pharmacotherapy
    Chapter 5. Review of Available Guidelines from Other Organizations
    Chapter 6. Psychosocial Interventions
    Chapter 7. Areas for Further Research in Individuals with Schizophrenia
    Chapter 8. Guideline Development Process
    Glossary of Terms
    Individuals and Organizations That Submitted Comments
    Appendix A. Clinical Questions
    Appendix B. Search Strategies, Study Selection, and Search Results
    Appendix C. Review of Research Evidence Supporting Guideline Statements
    Appendix D. Strength of Evidence

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