View Pricing

List Price


APA Members


20% off

APA Resident-Fellow Members


25% off

The American Psychiatric Publishing Textbook of Psychopharmacology, Fifth Edition

Edited by Alan F. Schatzberg, M.D., and Charles B. Nemeroff, M.D., Ph.D.

  • 2017
  • 1823 Pages
  • ISBN 978-1-61537-122-8
  • Item #37122
Hear the voices behind the most prominent psychiatric scholarship in Psychiatry Unbound.
Dr. Laura Roberts discusses the history and future of psychopharmacology with Alan. F. Schatzberg, M.D., editor of The American Psychiatric Association Publishing Textbook of Psychopharmacology.


The American Psychiatric Association Publishing Textbook of Psychopharmacology is an indispensable and comprehensive resource for clinicians and trainees who prescribe psychotropic medications. Updated to reflect the new DSM-5 classification, this revised Fifth Edition maintains the user-friendly structure of its predecessors while offering in-depth coverage of the latest research in pharmacological principles, classes of drugs, and psychiatric disorders. Introductory chapters provide a theoretical grounding in clinical applications, with topics ranging from neurotransmitters to brain imaging in psychopharmacology. The bulk of the book is devoted to various classes of drugs, including antidepressants, anxiolytics, antipsychotics, mood stabilizers, and other agents, with each class divided into chapters on specific drugs—either new or revised to include the latest findings and trends. Finally, the section on psychopharmacological treatment addresses evidence-based principles of clinical care for the full spectrum of mental disorders and conditions—from depression to chronic pain—as well as for specific populations and circumstances—from children and adolescents to psychiatric emergencies—offering information on topics such as medication selection, combination and maintenance dosing regimens, monitoring and management of side effects, and strategies for optimizing treatment response.

The book's beneficial features are many:

  • The section on principles of pharmacology has been revised and reorganized to incorporate recent discoveries from the fields of neurobiology, genetics, brain imaging, and epidemiology.
  • History and discovery, structure–activity relationships, pharmacological profiles, pharmacokinetics and disposition, mechanisms of action, indications and efficacy, side effects and toxicology, and drug–drug interactions are addressed for each agent. This consistent structure places the desired information at the clinician's fingertips and facilitates study for trainees.
  • Coverage of drugs approved since the last edition is thorough, encompassing new antidepressants (e.g., vortioxetine), new antipsychotics (e.g., cariprazine), and agents on the clinical horizon (e.g., ketamine).
  • More than 180 tables and graphs present critically important data in an accessible way.

A work of uncommon scientific rigor and clinical utility, The American Psychiatric Association Publishing Textbook of Psychopharmacology provides state-of-the-art information on both the principles and the practice of psychopharmacological treatment of psychiatric disorders.



    Part I: Principles of Pharmacology

    Chapter 1. Basic Principles of Molecular Biology and Genomics
    Chapter 2. Neurotransmitters
    Chapter 3. Genetics
    Chapter 4. Psychoneuroendocrinology
    Chapter 5. Brain–Immune System Interactions
    Chapter 6. Pharmacokinetics
    Chapter 7. Brain Imaging in Psychopharmacology

    Part II: Classes of Psychiatric Treatments Antidepressants and Anxiolytics

    Chapter 8. Monoamine Oxidase Inhibitors
    Chapter 9. Tricyclics
    Chapter 10. Fluoxetine
    Chapter 11. Sertraline
    Chapter 12. Paroxetine
    Chapter 13. Fluvoxamine
    Chapter 14. Citalopram
    Chapter 15. Trazodone and Nefazodone
    Chapter 16. Vortioxetine
    Chapter 17. Mirtazapine
    Chapter 18. Bupropion
    Chapter 19. Venlafaxine
    Chapter 20. Duloxetine, Milnacipran, and Levomilnacipran
    Chapter 21. Ketamine
    Chapter 22. Benzodiazepines
    Chapter 23. Buspirone


    Chapter 24. Classic Antipsychotics
    Chapter 25. Clozapine
    Chapter 26. Olanzapine
    Chapter 27. Quetiapine
    Chapter 28. Risperidone and Paliperidone
    Chapter 29. Aripiprazole
    Chapter 30. Ziprasidone
    Chapter 31. Asenapine
    Chapter 32. Iloperidone
    Chapter 33. Lurasidone
    Chapter 34. Cariprazine
    Chapter 35. Drugs to Treat Extrapyramidal Side Effects
    Drugs for Treatment of Bipolar Disorder
    Chapter 36. Lithium
    Chapter 37. Valproate Bowden
    Chapter 38. Carbamazepine
    Chapter 39. Gabapentin
    Chapter 40. Lamotrigine
    Chapter 41. Topiramate

    Other Agents

    Chapter 42. Agents for Cognitive Disorders
    Chapter 43. Sedative-Hypnotics
    Chapter 44. Psychostimulants and Wakefulness-Promoting Agents
    Chapter 45. Neurostimulation

    Part III: Psychopharmacological Treatment

    Chapter 46. Treatment of Depression
    Chapter 47. Treatment of Bipolar Disorder
    Chapter 48. Treatment of Anxiety and Related Disorders
    Chapter 49. Treatment of Schizophrenia
    Chapter 50. Treatment of Substance-Related Disorders
    Chapter 51. Treatment of Personality Disorders
    Chapter 52. Treatment of Eating Disorders
    Chapter 53. Treatment of Insomnia
    Chapter 54. Treatment of Chronic Pain
    Chapter 55. Treatment of Child and Adolescent Disorders
    Chapter 56. Treatment During Late Life
    Chapter 57. Psychopharmacology During Pregnancy and Lactation
    Chapter 58. Treatment of Psychiatric Emergencies
    Chapter 59. Treatment of Agitation and Aggression in the Elderly


    Elias Aboujaoude, M.D.
    W. Stewart Agras, M.D.
    Sultan Albrahim, M.D.
    Jacob S. Ballon, M.D., M.P.H.
    Raman Baweja, M.D.
    Elisabeth B. Binder, M.D., Ph.D.
    Pierre Blier, M.D., Ph.D.
    William V. Bobo, M.D., M.P.H.
    Charles L. Bowden, M.D.
    Kathleen T. Brady, M.D., Ph.D.
    Frank W. Brown, M.D.
    Mary F. Brunette, M.D.
    Peter F. Buckley, M.D.
    Matthew Byerly, M.D.
    Joseph R. Calabrese, M.D.
    Carla M. Canuso, M.D.
    Linda L. Carpenter, M.D.
    Robert H. Chew, Pharm.D.
    Leslie L. Citrome, M.D., M.P.H.
    Anita H. Clayton, M.D.
    Joseph F. Cubells, M.D., Ph.D.
    Darina Czamara, Ph.D.
    Daniella David, M.D.
    Jonathan R. T. Davidson, M.D.
    Karon Dawkins, M.D.
    Charles DeBattista, D.M.H., M.D.
    William C. Dement, M.D., Ph.D.
    D. P. Devanand, M.D.
    C. Lindsay DeVane, Pharm.D.
    Firdaus S. Dhabhar, Ph.D.
    Barbara D’Orio, M.D., M.P.A.
    Carolyn M. Drazinic, M.D., Ph.D.
    Elise Fallucco, M.D.
    Adriana E. Foster, M.D.
    Oliver Freudenreich, M.D.
    Mark A. Frye, M.D.
    Keming Gao, M.D., Ph.D.
    Steven J. Garlow, M.D., Ph.D.
    Alan J. Gelenberg, M.D.
    Donald C. Goff, M.D.
    Robert N. Golden, M.D.
    Rolando Gonzalez, M.D.
    Todd D. Gould, M.D.
    Alan I. Green, M.D.
    David V. Hamilton, M.D., M.A.
    Ebrahim Haroon, M.D.
    Karen J. Hartwell, M.D.
    Philip D. Harvey, Ph.D.
    Joseph H. Henry, M.D.
    Michele Hill, M.R.C.Psych.
    Eric Hollander, M.D.
    Jonathon R. Howlett, M.D.
    Dawn F. Ionescu, M.D.
    Ned H. Kalin, M.D.
    Masoud Kamali, M.D.
    Paul E. Keck Jr., M.D.
    David E. Kemp, M.D., M.S.
    Terence A. Ketter, M.D.
    Jessica Keverne, Ph.D.
    Roxanne Keynejad, M.A., M.B.B.S., M.R.C.P.
    Lorrin M. Koran, M.D.
    Ania Korszun, Ph.D., M.D., F.R.C.Psych.
    Venkatesh Basappa Krishnamurthy, M.D.
    K. Ranga Rama Krishnan, M.D.
    Kurt Kroenke, M.D.
    Andrew D. Krystal, M.D., M.S.
    Husseini K. Manji, M.D., F.R.C.P.C.
    Stephen R. Marder, M.D.
    David S. Mathai, B.S.
    Sanjay J. Mathew, M.D.
    Helen Mayberg, M.D.
    W. Vaughn McCall, M.D., M.S.
    William M. McDonald, M.D.
    Susan L. McElroy, M.D.
    Aimee L. McRae-Clark, Pharm.D.
    Thomas W. Meeks, M.D.
    Emmanuel Mignot, M.D., Ph.D.
    Andrew H. Miller, M.D.
    Kazuo Mishima, M.D., Ph.D.
    Marissa Miyazaki, M.D.
    Katherine Marshall Moore, M.D.
    Henry A. Nasrallah, M.D.
    J. Craig Nelson, M.D.
    Charles B. Nemeroff, M.D., Ph.D.
    John W. Newcomer, M.D.
    D. Jeffrey Newport, M.D.
    Linda Nicholas, M.D.
    Seiji Nishino, M.D., Ph.D.
    Douglas Noordsy, M.D.
    Sandhaya Norris, M.D.
    Carmine M. Pariante, Ph.D., M.D., F.R.C.Psych.
    Steven R. Pliszka, M.D.
    Bruce G. Pollock, M.D., Ph.D.
    Robert M. Post, M.D.
    Charles L. Raison, M.D.
    Mark M. Rasenick, Ph.D.
    Shona L. Ray-Griffith, M.D.
    Karl Rickels, M.D.
    Donald S. Robinson, M.D.
    Steven P. Roose, M.D.
    Patrick H. Roseboom, Ph.D.
    Jerrold F. Rosenbaum, M.D.
    Noriaki Sakai, D.V.M., Ph.D.
    Carl Salzman, M.D.
    Erika F. H. Saunders, M.D.
    Alan F. Schatzberg, M.D.
    S. Charles Schulz, M.D.
    David V. Sheehan, M.D., M.B.A.
    Richard C. Shelton, M.D.
    Brian J. Sherman, Ph.D.
    Amy L. Silberschmidt, M.D.
    Daphne Simeon, M.D.
    George M. Simpson, M.D.
    Joseph K. Stanilla, M.D.
    Murray B. Stein, M.D., M.P.H.
    Zachary N. Stowe, M.D.
    Martin T. Strassnig, M.D.
    Steven T. Szabo, M.D., Ph.D.
    Rajiv Tandon, M.D.
    Michael E. Thase, M.D.
    Marc L. van der Loos, M.D., Ph.D.
    Scott Van Sant, M.D.
    Karen Dineen Wagner, M.D., Ph.D.
    Po W. Wang, M.D.
    Margaret B. Weigel, M.D.
    Joanne D. Wojcik, Ph.D., P.M.H.C.N.S.-B.C.
    Tsung-Ung W. Woo, M.D., Ph.D.
    Yvonne S. Yang, M.D., Ph.D.
    Jiang-Zhou Yu, M.D., Ph.D.
    Charles F. Zorumski, M.D.

About the Authors

Alan F. Schatzberg, M.D., is Kenneth T. Norris Jr. Professor of the Department of Psychiatry and Behavioral Sciences at Stanford University School of Medicine in Stanford, California. He is also the Director of the Mood Disorders Center at Stanford University.

Charles B. Nemeroff, M.D., Ph.D., is Leonard M. Miller Professor and Chairman of the Department of Psychiatry and Behavioral Sciences at the University of Miami Miller School of Medicine in Miami, Florida.

Related Products

Become an APA Member
Join Now