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Psychopathology in the Genome and Neuroscience Era

Edited by Charles F. Zorumski, M.D., and Eugene H. Rubin, M.D., Ph.D.
American Psychopathological Association

  • ISBN 978-1-58562-242-9
  • Item #62242

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The fascinating Psychopathology in the Genome and Neuroscience Era brings together selected topics in psychiatric genetics, epidemiology and prevention, and neuroscience and education. This key reference integrates this information across the fields of genetics, epidemiology, and neuroscience to arrive at an understanding of where recent advances in genetics and neuroscience—advances that promise to enhance our understanding of human behavior and psychopathology—are likely to influence psychopathology research and education in the near future.

How will the field of psychopathology incorporate the coming avalanche of information generated by these recent advances? The answer will influence not only how mental health professionals diagnose and treat patients but also how the next generation of professionals is trained.

Chapters in this exciting compilation are based on individual talks by 20 international experts at the conceptual forefront of their respective fields given at the March 2003 American Psychopathological Association annual meeting. Organized into four main sections—the future of psychiatric genetics, diagnosis and prevention of psychiatric disorders, neurobiology and psychiatric disorders, and the future of psychiatric education—Psychopathology in the Genome and Neuroscience Era focuses on a broad range of topics:

  • The importance of a conceptual shift from identifying major genes for mental disorders to gaining an understanding of the role of which genes in which contexts, both biological and environmental, confer susceptibility to or protection from mental disorders or components thereof
  • Historical perspective of gene susceptibility to mental disorders, with the same possibilities for use and misuse of genotype data as now exist for significantly heritable traits such as intelligence, and for borderline traits such as criminal behavior and alcoholism
  • Reconceptualization of medicine and medical diagnoses to include molecular genetic components, including the importance of cell loss and neurogenesis in mood disorders
  • Major phenotypic problems inherent in all attempts to measure psychopathology, starting with how to achieve reliability, and how to advance from reliability to validity in future revisions of DSM and ICD classifications
  • Brain structural abnormalities in mood disorders; physiological cell death and whether or not this natural phenomenon can be converted into a pathological process, including the importance of cell loss and neurogenesis in mood disorders
  • The influence of scientific advances, workforce issues, and educational trends on psychiatric training

Psychopathology in the Genome and Neuroscience Era is a must-read reference work for anyone—practitioners, residents, and students alike—interested in the future of psychiatric genetics, epidemiology, and education.


  • Contributors
  • Preface
  • PART I: The Future of Psychiatric Genetics
  • Chapter 1. Bridging Genetics and Epidemiology of Mental Disorders
  • Chapter 2. New Genes for Human Behavior in Historical Perspective
  • Chapter 3. Redefining Early-Onset Disorders for Genetic Studies: Attention-Deficit/Hyperactivity Disorder and Autism
  • Chapter 4. Genetic Risk Factors for Late-Onset Alzheimer's Disease
  • PART II: Diagnosis and Prevention of Psychiatric Disorders
  • Chapter 5. Are There Phenotype Problems?
  • Chapter 6. Advancing From Reliability to Validity: The Challenge for the DSM-V/ICD-11 Revisions
  • Chapter 7. Prospects for Prevention of Mental Disorders in the Era of Genomic Medicine
  • PART III: Neurobiology and Psychiatric Disorders
  • Chapter 8. Brain Structural Abnormalities in Mood Disorders
  • Chapter 9. Neuroapoptosis During Synaptogenesis: A Final Common Path to Neurodevelopmental Disturbances
  • Chapter 10. Neurobiology, Neurogenesis, and the Pathology of Psychopathology
  • PART IV: The Future of Psychiatric Education
  • Chapter 11. Influence of Scientific Advances, Workforce Issues, and Educational Trends on Psychiatric Training
  • Chapter 12. Crisis in American Psychiatric Education: An Argument for the Inclusion of Research Training for All Psychiatric Residents
  • Index

About the Authors

Charles F. Zorumski, M.D., is Samuel B. Guze Professor and Head of Psychiatry at Washington University School of Medicine in St. Louis, Missouri.

Eugene H. Rubin, M.D., Ph.D., is Professor in the Department of Psychiatry and Vice Chair for Education at Washington University School of Medicine in St. Louis, Missouri.

Zorumski and Rubin have put together a nicely updated text from presentations at the 2003 American Psychopathological Association meetings. This book is ideally suited for academic psychiatrists and others interested in the field as it might evolve in the twentieth-first century. . . . It is an easy book to read, enjoy, and refer to as a remarkably astute appraisal of the current and future states of psychopathology.—Mark S. Gold, M.D., Distinguished Prof & Chief, McKnight Brain Inst, Depts of Psychiatry, Neuroscience, Anesthesiology, & Community Health & Family Medicine, Div Addiction Med, Univ of FL Coll of Med

This book is a thorough accounting of the advances made in recent years in the area of psychopathology and the uses of genomic sciences. With an outstanding cast of supporting authors, the editors have compiled a well thought out collection of information showcasing the integration of a wide range of fields into a comprehensive and useful book. A highly recommended text, providing pertinent evaluations of the current status of psychopathology in relation to recent revelations in genetics, genomics, and exciting new advances in psychiatry, clearly this book provides a solid foundation upon which future studies can be built.—Ming T. Tsuang, M.D., Ph.D., University Professor, University of California, Distinguished Professor of Psychiatry, and Director, Institute of Behavioral Genomics, Department of Psychiatry, University of California, San Diego; Director, Harvard Institute of Psychiatric Epidemiology and Genetics, Harvard Departments of Epidemiology and Psychiatry

Zorumski and Rubin's updated, multiauthored text, based on presentations at the 2003 American Psychopathological Association meeting is ideally suited for students and others interested in the future of psychopathology. . . . [It] is an easy book to read and enjoy. It is an convenient reference work, and it is a remarkably astute appraisal of the current and future states of psychopathology.—PsycCRITIQUES, 2/1/2006

This is an excellent new book covering the present and future research perspectives on the neuroscience of psychopathology. This book will help practicing psychiatrists to keep abreast of this rapidly changing field. No psychiatrist should be left behind!—Doody's Review Service, 2/1/2006

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