Plasma Homovanillic Acid in Schizophrenia
Implications for Presynaptic Dopamine Dysfunction
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Description
The role of dopamine in schizophrenia has been a significant area of research. The measurement of the major dopamine metabolite, homovanillic acid (HVA), in various body fluids, especially in blood plasma, is one of the primary methods to assess brain dopamine neuronal activity in schizophrenic patients.
Written by leading researchers in the field, Plasma Homovanillic Acid in Schizophrenia provides the most comprehensive and current collection of information on plasma HVA levels to be found anywhere. It provides a concise synthesis and critique of current data as well as interesting proposals for future research.
This book will be of great value to any serious student of the biology of schizophrenia and other psychiatric disorders involving abnormal levels of plasma HVA.
Contents
- Foreword. Plasma HVA as a tool to investigate presynaptic brain dopaminergic activity. Studies of the clinical correlates of elevated plasma catecholamine metabolites. Review of plasma HVA studies in schizophrenia. Plasma HVA and subtyping of schizophrenia. Catecholamines, their metabolites, and response to typical and atypical neuroleptics: toward an understanding of the mechanisms of action of neuroleptic drugs. Stabilizing systems in the brain. Early increase of plasma HVA during neuroleptic treatment: a tool for outcome prediction and for subtyping of schizophrenia. Dopaminergic plasticity in schizophrenia. Plasma HVA in schizotypal personality disorder. Methodological issues in interpreting plasma HVA levels in studies of schizophrenia. Methodological enhancements: the central dopaminergic index of plasma HVA. Afterword. Index.
About the Authors
Arnold J. Friedhoff, M.D., is Menas S. Gregory Professor of Psychiatry and Director of the Millhauser Laboratories at the New York University School of Medicine in New York, New York.
Farooq Amin, M.D., is Associate Chief of Psychiatry for Research at the Houston Veterans Affairs Medical Center and Director of Schizophrenia Research at the Baylor College of Medicine in Houston, Texas.
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