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Clinical and Research Perspectives

Edited by Paul J. Goodnick, M.D.

  • ISBN 978-0-88048-728-3
  • Item #8728

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Since the 1990 publication of Goodwin and Jamison's classic text on mania and bipolar and unipolar depression, Manic-Depressive Illness, there have been a number of significant advances in the research, diagnosis, and treatment of mania and bipolar disorder. Developed and written by experts at the forefront of these advances, Mania: Clinical and Research Perspectives provides a comprehensive overview of all recent developments on all aspects of mania.

Mania is divided into three sections: diagnostic considerations, biological aspects, and treatment. Diagnostic Considerations includes coverage of the diagnostic revisions in DSM-IV, special comorbidity issues in children and substance abuse, the differentiation of mood swing from bipolar disorder, and generational change and genetic linkage. Biological Aspects reviews the current state of knowledge in biochemistry and biological techniques such as gamma-aminobutyric acid (GABA) and brain imaging. Treatment thoroughly surveys all major treatment regimens for mania, including new drug therapies such as carbamazepine, valproate, clozapine, risperidone, verapamil, and nimodipine. This section also details new findings on the use of lithium and the risks for pregnant women and advances in psychotherapy. The book concludes with a summary that provides a historical perspective and directions for further research.

With the comprehensive coverage provided in Mania: Clinical and Research Perspectives, readers will be able to improve patient care through advanced diagnosis and treatment.


  • Diagnostic Considerations.

    Diagnostic revisions for DSM-IV. Creativity and mood disorder. Child and adolescent mania. Alcohol. Genetics.


    Serotonin. Catecholamines. Acetylcholine. Gamma-aminobutyric acid (GABA). Electrophysiology. Brain imaging.


    Lithium. Carbamazepine. Valproate. Clozapine. Calcium antagonists. Psychotherapy. Summary. Index.

About the Authors

Paul J. Goodnick, M.D., is Professor of Clinical Psychiatry and Director of the Mood Disorders Program at the University of Miami School of Medicine, Miami, Florida.

Mania will be of primary interest to researchers and to those psychiatrists with a special interest in the bipolar disorders. For the rest, Mania may provide the pleasure of dealing with bipolar disorders cleanly and clearly, and as something other than a cluttered dustbin of psychopathological ambiguity.—Bulletin of the Menninger Clinic

Mania. . . is a well written, easily accessible volume covering diagnosis, biology and treatment in three sections. . . well worth recommending to your local library.—International Journal of Psychiatry

There are many aspects of this book that make it truly outstanding as a guide and source for clinical and research perspectives on bipolar disorder. . . .Mania: Clinical and Research Perspectives completely and deftly accomplishes its goal of providing a backdrop for the current information on the etiology and treatment of mania in the context of the established knowledge that exists on the topic. . . .This book is highly recommended to those who work with individuals with a diagnosis of bipolar disorder or anyone who has a particular interest in this area.—Contemporary Psychology

Mania: Clinical and Research Perspectives provides a comprehensive, yet concise overview of the clinical and research aspects of mania. This state-of-the-art review is an important update on the very latest developments in our understanding and treatment of mania, and will be of enormous benefit to clinicians and researchers alike.—Robert N. Golden, M.D., Professor and Chair of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, North Carolina

A thorough, scholarly, yet highly readable volume that provides a fresh and informative update on the diagnosis, neurobiology, and treatment of bipolar disorder. This volume summarizes recent findings in the role of acetylcholine, catecholamines, gamma-aminobutyric acid, and serotonin systems in the condition. It goes on to detail the available efficacy data on lithium, anticonvulsants, atypical antipsychotics, calcium antagonists, and psychotherapy for these patients. Most importantly, it carefully reviews and summarizes the available scientific information in practical, clinically relevant terms that will surely enhance the quality of care we provide these patients.—A. John Rush, M.D., Professor of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas

Mania: Clinical and Research Perspectives is perfectly timed to assess our present state of basic and clinical knowledge regarding this disorder. Several of the most influential investigators in the area of bipolar disorder review the diagnostic, biological, and treatment advances over the past several years and in this context provide a fascinating glimpse as to where the field is moving. In basic research, the chapters on genetics and brain imaging were particularly well-written and instructive. . . . This work is well-organized, very readable, and will serve as an important bridge to the next series of discoveries in this area.—Philip G. Janicak, M.D., Professor of Psychiatry, University of Illinois at Chicago, Chicago, Illinois

I would highly recommend this book to all clinicians. The diagnostic and treatment sections will be relevant to anyone treating manic patients. The section on biology should be of interest to those who want to have more insight into the nature of this illness and why and how the therapeutic agents work.—Journal of Clinical Psychiatry

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