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Cognitive Dysfunction in Bipolar Disorder

A Guide for Clinicians

Edited by Joseph F. Goldberg, M.D., M.S., and Katherine Burdick, Ph.D.
Foreword by Frederick K. Goodwin, M.D.

  • ISBN 978-1-58562-258-0
  • Item #62258

Description

A growing body of clinical and experimental evidence shows that neurocognitive dysfunction is a fundamental—yet frequently ignored or misidentified—component of bipolar disorder. The first comprehensive book of its kind, Cognitive Dysfunction in Bipolar Disorder: A Guide for Clinicians compiles the latest data in neuropsychology, neuroimaging, neurogenetics, and functional outcomes research to enable clinicians to more effectively utilize pharmacological and psychotherapeutic techniques in their treatment of bipolar disorder.

This volume outlines and demystifies current knowledge about neuropsychological functioning in bipolar disorder in a reader-friendly, easy-to-understand guide for practitioners. Its 12 chapters, written by 23 internationally-renowned expert contributors, examine such topics as attentional and executive functioning, neuroimaging and genetic correlates of cognitive functioning, pharmacological strategies, bipolar disorder in pediatric patients, and cognition across the life span.

The book also comes with the added benefit of


  • A review of neurocognitive domains, examples of their operation in everyday life, the neuroanatomical regions with which they are associated, and common tests used to assess their function
  • Summarized data from large-scale clinical trials, including the National Institute of Mental Health Antipsychotic Trials of Intervention Effectiveness (CATIE) study
  • Take-home points at the end of each chapter summarizing main concepts and “clinical pearls”
  • Case studies and illustrative examples depicting the application of specific neurocognitive principles

Using relevant applications from cognitive neuroscience, Cognitive Dysfunction in Bipolar Disorder provides clinicians with a comprehensive overview of astounding breakthroughs in the assessment and treatment of patients with bipolar disorder. It plows new ground in the mental health industry, correcting distortions and laying the foundation for future clinical research in this rapidly expanding field.

Contents

Contributors
Foreword
Preface
Chapter 1. Overview and introduction: dimensions of cognition and measures of cognitive function
Chapter 2. Attentional and executive functioning in bipolar disorder
Chapter 3. Memory deficits associated with bipolar disorder
Chapter 4. The endophenotype concept: examples from neuropsychological and neuroimaging studies of bipolar disorder
Chapter 5. Impact of mood, anxiety, and psychotic symptoms on cognition in patients with bipolar disorder
Chapter 6. Improving psychotherapy practice and technique for bipolar disorder: lessons from cognitive neuroscience
Chapter 7. Adverse cognitive effects of psychotropic medications
Chapter 8. Pharmacological strategies to enhance neurocognitive function
Chapter 9. Cognitive dysfunction in children and adolescents with bipolar disorder: Relative contribution of bipolar disorder and attention-deficit/hyperactivity disorder
Chapter 10. Cognition and functional outcome in bipolar disorder
Chapter 11. Cognition across the life span: Clinical implications for older adults with bipolar disorder
Chapter 12. Summary and assessment recommendations for practitioners
Index

Contributors

Carrie E. Bearden, Ph.D.
Katherine E. Burdick, Ph.D.
Catherine M. Cahill, M.Sc., M.Psychol.
Luke Clark, D.Phil.
Colin M. DeFreitas, M.A.
Melissa P. DelBello, M.D.
Safa Elgamal, M.D., M.Sc., Ph.D.
x Cognitive Dysfunction in Bipolar Disorder
David C. Glahn, Ph.D.
Joseph F. Goldberg, M.D.
Terry E. Goldberg, Ph.D.
Guy Goodwin, M.D.
Glenda MacQueen, M.D., Ph.D.
Gin S. Malhi, M.B.Ch.B., B.Sc. (Hons), M.R.C.Psych.,
F.R.A.N.Z.C.P., M.D.
Anabel Martinez-Aran, Ph.D.
David J. Miklowitz, Ph.D.
Philip Mitchell, M.B., B.S., M.D., F.R.A.N.Z.C.P., F.R.C.Psych.
Cory F. Newman, Ph.D.
Paula K. Shear, Ph.D.
Marta Sokolowska, Ph.D.
Ivan J. Torres, Ph.D.
Eduard Vieta, M.D., Ph.D.
Lakshmi N. Yatham, M.B.B.S., F.R.C.P.C., M.R.C.Psych.
L. Trevor Young, M.D., Ph.D.

About the Authors

Joseph F. Goldberg, M.D., is Associate Clinical Professor of Psychiatry at Mount Sinai School of Medicine in New York, New York; and Director of the Affective Disorders Research Program at Silver Hill Hospital in New Canaan, Connecticut.

Katherine E., Burdick, Ph.D., is Assistant Professor of Psychiatry at Albert Einstein College of Medicine in The Bronx, New York; and Director of the Neurocognitive Assessment Unit in the Division of Psychiatry Research of The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, in Glen Oaks, New York.

Cognitive Dysfunction in Bipolar Disorder: A Guide for Clinicians reviews the issue of cognitive dysfunction in bipolar disorder and presents useful clinical material, including treatment effects and the differential diagnosis of ADHD and bipolar disorder. The experts who contributed to this volume have done an excellent job of synthesizing research findings and making them clinically relevant. This text is a handy reference guide for the clinician’s library.—David L. Dunner, M.D., F.A.C.Psych, Director, Center for Anxiety and Depression, Mercer Island, WA and Professor Emeritus, Department of Psychiatry and Behavioral Sciences, University of Washington


This is clearly the definitive work on this important topic. Many even euthymic patients with bipolar disorder have considerable cognitive dysfunction, often directly related to the number of prior episodes or hospitalizations experienced. The data are authoritatively reviewed; take home points summarized in each chapter, and treatment strategies highlighted, making it particularly accessible and worthwhile for clinicians.—Robert Post, M.D., Professor of Psychiatry, The George Washington University, Pennsylvania State University


This is an outstanding compendium of information on the cognitive aspects of bipolar illness and the impact of medication and mood states on cognition. This book comprehensively reviews and discusses comorbidities (e.g., ADHD) that may contribute to the cognitive disturbances seen in patients with bipolar illness. Several chapters additionally address the functional outcomes in patients with cognitive disturbances. Potential pharmacologic remedies that may enhance neurocognitive function are reviewed. A chapter devoted to neuroimaging and genetic correlates emphasizes important issues around cognition as an endophenotype. I highly recommend this book for clinicians and researchers alike.—Lori Altshuler, M.D., Julia S. Gouw Professor in Mood Disorders Research and Director, UCLA Mood Disorders Research Program, Department of Psychiatry, David Geffen School of Medicine at UCLA

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