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Bipolar Disorders

Clinical Course and Outcome

Edited by Joseph F. Goldberg, M.D., M.S., and Martin Harrow, Ph.D.

  • ISBN 978-0-88048-768-9
  • Item #8768


Biopolar disorder has served as a principal point of focus for modern psychiatric research since the advent of the psychopharmacological revolution. Yet, the disparity between optimal and typical care for biopolar disorder is perhaps nowhere larger, and its human and economic impact nowhere greater.

An important and much-needed resource, Bipolar Disorders: Clinical Course and Outcome relates empirical data on outcome with practical information on the prognosis, course, and potential complications of bipolar disorders in the modern era.

Pulling together current knowledge on bipolar disorders from leading investigators in the field, Bipolar Disorders provides a concise, up-to-date summary of affective relapse, comorbid psychopathology, functional disability, and psychosocial outcome in contemporary bipolar disorders. Important issues regarding pharmacoeconomics and the burden of disease are presented in conjunction with a discussion of mania through the life cycle and a summary of clinical and treatment implications.

In addition, this timely resource covers the effect of lithium and anticonvulsants on outcome during controlled and naturalistic treatment; manic outcome in relation to specific comorbidities or subtypes of illness for mixed mania, alcoholism or other substance abuse, rapid-cycling bipolar disorders, hypomania, and comorbid anxiety disorders; individual psychotherapy and family psychoeducation; and the role of public sector psychiatry and community-based treatment programs for chronic bipolar illness.

As part of the Clinical Practice Series of the American Psychiatric Press, this book integrates current clinical research findings with practical clinical applications, providing a broad overview of course and outcome for bipolar patients treated under typical treatment conditions. Aimed at both clinicians and investigators, this book consciously relates naturalistic follow-up studies in mania to the routine clinical management of bipolar disorders over time.


  • Foreword. Preface. Poor-outcome bipolar disorders. Lithium prophylaxis of bipolar disorder in ordinary clinical conditions: patterns of long-term outcome. Syndromal and psychosocial outcome in bipolar disorder: a complex and circular relationship. New psychotherapies for bipolar disorder. Long-term outcome of anticonvulsants in affective disorders. Mixed-state bipolar disorders: outcome data from the NIMH Collaborative Program on the Psychobiology of Depression. Depression in the course of bipolar disorder. Comparison of open versus blinded studies in bipolar disorder. Bipolar disorder and comorbid substance use disorder. Alcoholism in bipolar disorder. Rapid-cycling bipolar affective disorder. Bipolar II disorder: the importance of hypomania. The paradox of anxiety syndromes comorbid with the bipolar illnesses. Psychosocial treatment of bipolar disorder in the public sector: Program for Assertive Community Treatment model. Summary of findings on the course and outcome of bipolar disorders. Index.

About the Authors

Joseph F. Goldberg, M.D., is Assistant Professor of Psychiatry at The Joan and Sanford I. Weill Medical College of Cornell University and the Director of the Bipolar Disorders Research Clinic at the Payne Whitney Clinic, and Presbyterian Hospital in New York, New York.

Martin Harrow, Ph.D., is Professor and Director of Psychology in the Department of Psychiatry at the University of Illinois–College of Medicine in Chicago.

I recommend this book to anyone interested in working with bipolar patients. Certainly I recommend it to be stocked in every library with a clinical readership.—Dominic Lam, Behavior Research and Therapy

The chapters are will written and with clear markers on the contents and often have clinical cases highlighting some of the key management problems.—International Review of Psychiatry

This book provides a good overview of the major phenotypes of this disorder and comorbid states in adults. . . . The book does provide a useful overview of the emergence of new classes of therapeutic drugs for bipolar disorder and the appropriate blending of psychtherapeutic and pharmacologic techniques.—Journal of Clinical Psychiatry

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