Childhood Onset of 'Adult' Psychopathology
Clinical and Research Advances
Description
Age at onset studies have been an important approach to understanding disease across all medical specialties. Over the last few decades, genetic research has led to the identification of unique genes and, in some cases, physiologically different disorders. These advances bring us closer to identifying genetic vulnerability and implementing prevention programs for psychopathology.
Childhood Onset of “Adult” Psychopathology: Clinical and Research Advances provides an understanding of the childhood onsets of adult psychiatric disorders, including when and in what sequence psychiatric disorders begin in childhood, and how these disorders evolve over the life span. This book examines
- Studies on the growing volume of data on very early forms of depression, criminality, alcoholism, schizophrenia, and anxiety
- Genetics, evolution, and the significance of age at onset in terms of individual variability and the course of disease
- The biological manner in which early-onset disorders progress
- New insights into the disease etiology of schizophrenia and the neurodevelopmental hypothesis
- The long-debated subject of whether depressive disorder in preadolescent children is the same as depressive disorder in adults and studies of individuals at risk for disorders of anxiety and depression
- The implications for prevention of adult psychiatric disorders, alcoholism, and antisocial personality disorder
Complete with extensive references and tables, this text provides practitioners with a better understanding of adult psychopathology and insight into early detection and prevention methods.
Contents
- Contributors
Introduction
Part I: Age at Onset: Mechanisms and Methods
Chapter 1. Genetics of Early-Onset Manic-Depressive Illness and Schizophrenia
Chapter 2. Genetics, Evolution, and Age at Onset of Disease
Chapter 3. Trinucleotide Expansion in the FMR1 Gene and Fragile X Syndrome
Part II: Neurodevelopmental Pathways to “Adult” Psychiatric Disorders: Triggers of Disease Onset
Chapter 4. Biological Markers as Precursors to Schizophrenia: Specificity, Predictive Ability, and Etiological Significance
Chapter 5. PANDAS: A New “Species” of Childhood-Onset Obsessive-Compulsive Disorder?
Chapter 6. Prenatal Antecedents of Neuropsychiatric Disorder Over the Life Course: Collaborative Studies of United States Birth Cohorts
Part III: Schizophrenia: Specific Disorders
Chapter 7. Late-Onset Schizophrenia: New Insights Into Disease Etiology
Chapter 8. Childhood-Onset Schizophrenia: What Can It Teach Us?
Chapter 9. Neurodevelopmental Hypothesis of Schizophrenia 12 Years On: Data and Doubts
Part IV: Depression and Anxiety
Chapter 10. Childhood Depression: Is It the Same Disorder?
Chapter 11. Offspring at Risk: Early-Onset Major Depression and Anxiety Disorders Over a Decade
Chapter 12. When Is Onset? Investigations Into Early Developmental Stages of Anxiety and Depressive Disorders
Chapter 13. Very-Early-Onset Bipolar Disorder: Does It Exist?
Part V: Early Prevention of Adult Psychiatric Disorders
Chapter 14. Prevention of Mental Disorders and the Study of Developmental Psychopathology: A Natural Alliance
Chapter 15. Prevention of Alcoholism: Reflections of a Naturalist
Chapter 16. Prevention of Antisocial Personality Disorder
Index
About the Authors
Judith L. Rapoport, M.D. is Chief of the Child Psychiatry Branch at the National Institute of Mental Health in Bethesda, Maryland. Dr. Rapoport is a graduate of Swarthmore College and Harvard Medical school. Her clinical training was at the Massachusetts Mental Health Center, and at Children’s Hospital in Washington, DC. Her research training was at the Karolinska Hospital in Stockholm and the Laboratory of Psychology at the National Institute of Mental Health (NIMH). Her research has covered several aspects of child psychiatry including diagnosis, childhood hyperactivity, pediatric psychopharmacology and author of three professional books and over two hundred research journal articles. She is currently Chief of the Child Psychiatry Branch, National Institute of Mental Health. Work in her branch on Attention Deficit Hyperactivity Disorder has recently focused on normal and abnormal brain development.
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